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A new indicator of sperm age may be a predictor of pregnancy success – ScienceDaily

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A new technique for measuring the age of male sperm has the potential to predict the success and time it takes to conceive, according to a recently published study by scientists from Wayne University School of Medicine.

“Epigenetic sperm clocks are linked to pregnancy outcomes in the general population,” (cited in an article here) published in the journal Human Reproduction found that epigenetic semen aging hours may act as a new biomarker for predicting mating time. The results also emphasize the importance of the male partner in reproductive success.

Chronological age is a significant determinant of reproductive capacity and success among couples trying to conceive, but chronological age does not include aggregate genetic and external environmental conditions – factors, and thus serves as an operator measure of “true” biological the age of the cells, ”said J. Richard Pilsner, Ph.D., lead author of the study. Dr. Pilsner is Robert J. Falcon, MD, Department of Molecular Obstetrics and Gynecology and Director of Molecular Genetics and Infertility at the CS Mott Center for Human Growth and Development WSU. “Sperm quality results using World Health Organization guidelines have been used to assess male infertility for decades, but they remain poor predictors of reproductive outcomes. Thus, the ability to record biological sperm age may be a new platform for better assessment especially among infertile couples. ”

Epigenetic sperm aging is biological, not chronological, sperm aging. The study found a 17% lower overall probability of pregnancy after 12 months for couples with male partners in the older categories of epigenetic sperm aging compared to the young. The study involved 379 male partners of couples who stopped using contraception in order to conceive.

The study also found higher epigenetic aging of sperm in men who smoke.

The results, according to Dr. Pilsner, show that higher epigenetic semen aging is associated with longer pregnancies in couples who did not receive infertility treatment, and among couples who reached pregnancy with shorter pregnancies.

The strong link between epigenetic sperm aging and the likelihood of pregnancy and its slowing or reversal through lifestyle choices and / or pharmacological interventions requires further investigation. In addition, because older parents have an increased risk of developing children with adverse neurological outcomes, it is important to understand the potential link epigenetic semen aging to children’s health and development.

“There is an urgent need for new measures of male fertility to assess overall reproductive success among couples in the general population,” Dr. Pilsner said. “These data suggest that our epigenetic sperm clock can meet this need as a new biomarker that predicts pregnancy success among couples who do not seek treatment for fertility. While the chronological age of both partners remains a significant predictor of reproductive success, our clock This summary of both external and internal factors that stimulate biological semen aging is a clinical indicator of the biological age of semen because it allows couples in the general population to realize their likelihood of becoming pregnant during natural intercourse, thereby informing and informing about sexual intercourse. infertility treatment decisions. “

Dr Pilsner advised that because the subjects were mostly Caucasian, larger and more diverse cohorts were needed to confirm the link between epigenetic sperm aging and the success of paired pregnancies in other races and ethnic groups.

The study was funded in part by grants from the National Institute of Environmental Sciences of the National Institutes of Health (R01ES028298 and P30 ES020957); and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (N01-HD-3-3355, N01-HD-3-3356, and N01-HD-3-3358).

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