Home Career Long-term high-fat diet increases waist size and shrinks brain – ScienceDaily

Long-term high-fat diet increases waist size and shrinks brain – ScienceDaily


New research shows that fatty foods may not only increase your waistline, but also harm your brain.

An international study led by UniSA neuroscientists Professor Xin-Fu Zhou and Associate Professor Larissa Bobrowska found a clear link between mice fed a high-fat diet that led to diabetes for 30 weeks and the subsequent decline in their cognitive abilities, including the development of anxiety. , depression and worsening Alzheimer’s disease.

Mice with impaired cognitive function were also more likely to gain excess weight due to poor metabolism caused by brain changes.

Researchers from Australia and China published their results in Metabolic brain disease.

UniSA neuropathologist and biochemist Associate Professor Larisa Babrovskaya says the study adds to the growing body of evidence linking chronic obesity and diabetes to Alzheimer’s disease, which is predicted to reach 100 million cases by 2050.

“Obesity and diabetes impair the central nervous system, exacerbating mental disorders and cognitive decline. We demonstrated this in our study on mice,” says Associate Professor Babrovskaya.

In the study, mice were randomly assigned to either a standard diet or a high-fat diet for 30 weeks, starting at eight weeks of age. Food intake, body weight, and glucose levels were monitored at various time intervals, along with glucose and insulin tolerance tests and cognitive dysfunction.

Mice fed a high-fat diet gained more weight, developed insulin resistance and began to behave abnormally compared to those fed a standard diet.

Mice with genetically modified Alzheimer’s disease showed significant cognitive impairment and pathological changes in the brain when fed a high-fat diet.

“In people with obesity, the risk of developing depression increases by about 55 percent, and diabetes doubles this risk,” says Associate Professor Babrovskaya.

“Our findings underscore the importance of addressing the global obesity epidemic. The combination of obesity, age, and diabetes is highly likely to lead to cognitive decline, Alzheimer’s disease, and other mental health disorders.”

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Materials is provided University of South Australia. Note: Content can be edited for style and length.

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